[HTML][HTML] Maturation and release of interleukin-1β by lipopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors
A Colomar, V Marty, C Médina, C Combe… - Journal of Biological …, 2003 - ASBMB
The P2X 7 receptor, mainly expressed by immune cells, is a ionotropic receptor activated by
high concentration of extracellular ATP. It is involved in several processes relevant to
immunomodulation and inflammation. Among these processes, the production of
extracellular interleukin-1β (IL-1β), a pro-inflammatory cytokine, plays a major role in the
activation of the cytokine network. We have investigated the role of P2X 7 receptor and of an
associated calcium-activated potassium conductance (BK channels) in IL-1β maturation and …
high concentration of extracellular ATP. It is involved in several processes relevant to
immunomodulation and inflammation. Among these processes, the production of
extracellular interleukin-1β (IL-1β), a pro-inflammatory cytokine, plays a major role in the
activation of the cytokine network. We have investigated the role of P2X 7 receptor and of an
associated calcium-activated potassium conductance (BK channels) in IL-1β maturation and …