[HTML][HTML] Injection of flagellin into the host cell cytosol by Salmonella enterica serotype Typhimurium
YH Sun, HGÁ Rolán, RM Tsolis - Journal of Biological Chemistry, 2007 - ASBMB
Bacterial flagellins are potent inducers of innate immunity. Three signaling pathways have
been implicated in the sensing of flagellins; these involve toll-like receptor 5 (TLR5) and the
cytosolic proteins Birc1e/Naip5 and Ipaf. Although the structural basis of TLR5-flagellin
interaction is known, little is known about how flagellin enters the host cell cytosol to induce
signaling via Birc1e/Naip5 and Ipaf. Here we demonstrate for the first time the translocation
of bacterial flagellin into the cytosol of host macrophages by the vacuolar pathogen …
been implicated in the sensing of flagellins; these involve toll-like receptor 5 (TLR5) and the
cytosolic proteins Birc1e/Naip5 and Ipaf. Although the structural basis of TLR5-flagellin
interaction is known, little is known about how flagellin enters the host cell cytosol to induce
signaling via Birc1e/Naip5 and Ipaf. Here we demonstrate for the first time the translocation
of bacterial flagellin into the cytosol of host macrophages by the vacuolar pathogen …