NLRC4/IPAF: a CARD carrying member of the NLR family
FS Sutterwala, RA Flavell - Clinical immunology, 2009 - Elsevier
The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate
immune responses and cell death pathways. Recent findings show that the NLR family
member NLRC4 (also known as IPAF) has important roles in innate immune responses to
Gram-negative bacteria. Macrophages infected with Legionella pneumophila, Salmonella
typhimurium, Shigella flexneri, or Pseudomonas aeruginosa activate caspase-1 in an
NLRC4-dependent manner leading to macrophage cell death and the release of …
immune responses and cell death pathways. Recent findings show that the NLR family
member NLRC4 (also known as IPAF) has important roles in innate immune responses to
Gram-negative bacteria. Macrophages infected with Legionella pneumophila, Salmonella
typhimurium, Shigella flexneri, or Pseudomonas aeruginosa activate caspase-1 in an
NLRC4-dependent manner leading to macrophage cell death and the release of …