Biochemical models of hereditary pancreatitis
M Sahin-Tóth - Endocrinology and Metabolism Clinics, 2006 - endo.theclinics.com
The past decade has witnessed remarkable progress in the genetics of chronic pancreatitis.
Mutations of the PRSS1 gene encoding cationic trypsinogen and the SPINK1 gene
encoding pancreatic secretory trypsin inhibitor were found in association with hereditary,
familial, or sporadic chronic pancreatitis; and the genotype-phenotype correlations have
been characterized at the clinical level. Despite these accomplishments, the understanding
of the molecular mechanisms through which PRSS1 and SPINK1 mutations cause chronic …
Mutations of the PRSS1 gene encoding cationic trypsinogen and the SPINK1 gene
encoding pancreatic secretory trypsin inhibitor were found in association with hereditary,
familial, or sporadic chronic pancreatitis; and the genotype-phenotype correlations have
been characterized at the clinical level. Despite these accomplishments, the understanding
of the molecular mechanisms through which PRSS1 and SPINK1 mutations cause chronic …