ContextCarcinogens associated with head and neck squamous cell carcinoma (SCC)
genesis should inflict genomic alterations not only on the epithelium but also the
mesenchyme of the aerodigestive tract. Therefore, the apparently nonmalignant stroma
surrounding the tumor epithelium can acquire genomic alterations and contribute to cancer
initiation and progression. ObjectivesTo determine compartment-specific loci of loss of
heterozygosity or allelic imbalance (LOH/AI) and to identify which genomic alterations …