[HTML][HTML] Oncogenic ras represses transforming growth factor-β/Smad signaling by degrading tumor suppressor Smad4
D Saha, PK Datta, RD Beauchamp - Journal of Biological Chemistry, 2001 - ASBMB
The loss of growth-inhibitory responses to transforming growth factor-β (TGF-β) is a frequent
consequence of malignant transformation. Smad2, Smad3, and Smad4 proteins are
important mediators of the antiproliferative responses to TGF-β and may become inactivated
in some human cancers. Epithelial cells harboring oncogenic Ras mutations often exhibit a
loss of TGF-β antiproliferative responses. To further investigate the effect of oncogenic Ras
in TGF-β signaling, we used an isopropyl-1-thio-β-d-galactopyranoside-inducible …
consequence of malignant transformation. Smad2, Smad3, and Smad4 proteins are
important mediators of the antiproliferative responses to TGF-β and may become inactivated
in some human cancers. Epithelial cells harboring oncogenic Ras mutations often exhibit a
loss of TGF-β antiproliferative responses. To further investigate the effect of oncogenic Ras
in TGF-β signaling, we used an isopropyl-1-thio-β-d-galactopyranoside-inducible …