[HTML][HTML] Regulatory mechanism of matrix metalloprotease-2 enzymatic activity by factor Xa and thrombin
BH Koo, MY Park, OH Jeon, DS Kim - Journal of biological chemistry, 2009 - ASBMB
Matrix metalloprotease (MMP)-2 plays a key role in many biological and pathological
processes related to cell migration, invasion, and mitogenesis. MMP-2 is synthesized as a
zymogen that is activated through either a conformational change or proteolysis of the
propeptide. Several activating enzymes for pro-MMP-2 have been proposed, including
metalloproteases and serine proteases. The mechanism of pro-MMP-2 activation by
metalloproteases is well established, and the most studied activation mechanism involves …
processes related to cell migration, invasion, and mitogenesis. MMP-2 is synthesized as a
zymogen that is activated through either a conformational change or proteolysis of the
propeptide. Several activating enzymes for pro-MMP-2 have been proposed, including
metalloproteases and serine proteases. The mechanism of pro-MMP-2 activation by
metalloproteases is well established, and the most studied activation mechanism involves …