A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
P Stephens, S Edkins, H Davies, C Greenman, C Cox… - Nature …, 2005 - nature.com
Nature genetics, 2005•nature.com
We examined the coding sequence of 518 protein kinases,∼ 1.3 Mb of DNA per sample, in
25 breast cancers. In many tumors, we detected no somatic mutations. But a few had
numerous somatic mutations with distinctive patterns indicative of either a mutator
phenotype or a past exposure.
25 breast cancers. In many tumors, we detected no somatic mutations. But a few had
numerous somatic mutations with distinctive patterns indicative of either a mutator
phenotype or a past exposure.
Abstract
We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
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