The purposes of these studies were to produce a small animal model of arterial thrombosis
for study of novel antithrombotic agents, to validate a simple temperature index of occlusive
thrombosis, and to describe the composition of the thrombus. Small thermocouple
transducers were fabricated from readily available materials. A thermocouple was inserted
under a carotid artery of the anesthetized rat and vessel temperature was recorded
continuously. Arterial injury was induced by FeC1 3 solution applied topically to the artery …