Conversion from white to brown adipocytes: a strategy for the control of fat mass?
C Tiraby, D Langin - Trends in Endocrinology & Metabolism, 2003 - cell.com
C Tiraby, D Langin
Trends in Endocrinology & Metabolism, 2003•cell.comUnderstanding the mechanisms governing the acquisition of white and brown adipocyte
phenotypes might have implications for the physiopathology of, and therapeutic strategies
for obesity. Peroxisome proliferator-activated recetor γ (PPARγ) and its coactivators, PGC-1α
and SRC-1, influence brown adipocyte metabolism and development. Ectopic expression of
PGC-1α induces the expression of brown adipocyte genes in human white adipocytes. The
changes in gene expression promote stimulation of fatty acid oxidation. There is now …
phenotypes might have implications for the physiopathology of, and therapeutic strategies
for obesity. Peroxisome proliferator-activated recetor γ (PPARγ) and its coactivators, PGC-1α
and SRC-1, influence brown adipocyte metabolism and development. Ectopic expression of
PGC-1α induces the expression of brown adipocyte genes in human white adipocytes. The
changes in gene expression promote stimulation of fatty acid oxidation. There is now …
Abstract
Understanding the mechanisms governing the acquisition of white and brown adipocyte phenotypes might have implications for the physiopathology of, and therapeutic strategies for obesity. Peroxisome proliferator-activated recetor γ (PPARγ) and its coactivators, PGC-1α and SRC-1, influence brown adipocyte metabolism and development. Ectopic expression of PGC-1α induces the expression of brown adipocyte genes in human white adipocytes. The changes in gene expression promote stimulation of fatty acid oxidation. There is now evidence to support the concept of an alteration in energy balance through a conversion of white to brown adipose tissue.
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