[HTML][HTML] α-Synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

CE Ellis, PL Schwartzberg, TL Grider, DW Fink… - Journal of Biological …, 2001 - ASBMB
α-Synuclein (α-Syn) is implicated in the pathogenesis of Parkinson's Disease, genetically
through missense mutations linked to early onset disease and pathologically through its
presence in Lewy bodies. α-Syn is phosphorylated on serine residues; however, tyrosine
phosphorylation of α-Syn has not been established (1, 2). A comparison of the protein
sequence between Synuclein family members revealed that all four tyrosine residues of α-
Syn are conserved in all orthologs and β-Syn paralogs described to date, suggesting that …