The reduction of hypoxia-induced and reoxygenation-induced apoptosis in rat islets by epigallocatechin gallate

Y Hara, M Fujino, K Adachi, XK Li - Transplantation proceedings, 2006 - Elsevier
The survival of transplanted tissue is affected by the detrimental consequences of hypoxia
followed by reoxygenation. The majority of transplanted cells undergo apoptosis due to
hypoxia and reoxygenation (H/R) injury, but protection from H/R has been less examined. In
this study, we examined whether epigallocatechin gallate (EGCG) protected rat islets from
H/R injury. Rat islets, freshly prepared from F344 rat strain by collagenase digestion and
density centrifugation, were seeded in triplicate at concentrations of 100 per well in 24-well …