[HTML][HTML] Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species
X Li, H Chen, PN Epstein - Journal of Biological Chemistry, 2004 - ASBMB
Islet transplantation is a promising therapy for Type 1 diabetes, but many attempts have
failed due to early graft hypoxia or immune rejection, which generate reactive oxygen
species (ROS). In the current study, we determined that transgenic overexpression of the
antioxidant metallothionein (MT) in pancreatic beta cells provided broad resistance to
oxidative stress by scavenging most kinds of ROS including H 2 O 2, peroxynitrite radical
released from streptozotocin, 3-morpholinosydnonimine (SIN-1), and superoxide radical …
failed due to early graft hypoxia or immune rejection, which generate reactive oxygen
species (ROS). In the current study, we determined that transgenic overexpression of the
antioxidant metallothionein (MT) in pancreatic beta cells provided broad resistance to
oxidative stress by scavenging most kinds of ROS including H 2 O 2, peroxynitrite radical
released from streptozotocin, 3-morpholinosydnonimine (SIN-1), and superoxide radical …