[HTML][HTML] Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
M Riewald, W Ruf - Journal of Biological Chemistry, 2005 - ASBMB
Activated protein C (APC) has anti-inflammatory and vascular protective effects independent
of anticoagulation. We previously identified the prototypical thrombin receptor, protease-
activated receptor-1 (PAR1), as part of a novel APC-endothelial cell protein C receptor
(EPCR) signaling pathway in endothelial cells. Experiments in wild-type and PAR1-/-mice
demonstrated that intravenous injection of APC leads to PAR1-dependent gene induction in
the lung. The vascular endothelium undergoes profound changes in severe sepsis, the …
of anticoagulation. We previously identified the prototypical thrombin receptor, protease-
activated receptor-1 (PAR1), as part of a novel APC-endothelial cell protein C receptor
(EPCR) signaling pathway in endothelial cells. Experiments in wild-type and PAR1-/-mice
demonstrated that intravenous injection of APC leads to PAR1-dependent gene induction in
the lung. The vascular endothelium undergoes profound changes in severe sepsis, the …