Transfusion-related acute lung injury (TRALI) is an underreported complication of
transfusion therapy, and it is the third most common cause of transfusion-associated death.
TRALI is defined as noncardiogenic pulmonary edema temporally related to transfusion
therapy. The diagnosis of TRALI relies on excluding other diagnoses such as sepsis, volume
overload, and cardiogenic pulmonary edema. Supportive diagnostic evidence includes
identifying neutrophil or human leukocyte antigen (HLA) antibodies in the donor or recipient …