Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats
Y Terada, H Tanaka, T Okado… - Journal of the …, 2003 - journals.lww.com
The Wnt-β-catenin pathway plays key roles in embryogenesis. Wnt-4 is known to be
expressed in the mesonephric duct in embryonic development. It is tempting to speculate
that the Wnt-4-β-catenin pathway contributes to the recovery from acute renal failure (ARF).
This study used an in vivo model of ARF rats to clarify the significance of the Wnt-4-β-catenin
pathway in ARF. ARF was induced by clamping the rat left renal artery for 1 h. At 3, 6, 12, 24,
48, and 72 h after reperfusion, whole kidney homogenate and total RNA were extracted for …
expressed in the mesonephric duct in embryonic development. It is tempting to speculate
that the Wnt-4-β-catenin pathway contributes to the recovery from acute renal failure (ARF).
This study used an in vivo model of ARF rats to clarify the significance of the Wnt-4-β-catenin
pathway in ARF. ARF was induced by clamping the rat left renal artery for 1 h. At 3, 6, 12, 24,
48, and 72 h after reperfusion, whole kidney homogenate and total RNA were extracted for …