The zebrafish gene, mind bomb (mib), encodes a protein that positively regulates of the
Delta-mediated Notch signaling. It interacts with the intracellular domain of Delta to promote
its ubiquitination and endocytosis. In our search for the mouse homologue of zebrafish mind
bomb, we cloned two homologues in the mouse genome: a mouse orthologue (mouse mib1)
and a paralogue, named mind bomb-2 (mib2), which is evolutionarily conserved from
Drosophila to human. Both Mib1 and Mib2 have an E3 ubiquitin ligase activity in their C …