Mutations in Drosophila neuralized (Dneur) result in a variety of developmental defects that
closely resemble those of Notch mutants and other Notch pathway mutants. However, mice
with disrupted neur1 do not show any aberrant cell fate specifications in neurogenesis and
somitogenesis. Thus, we speculated that other vertebrate neur homolog (s) might
compensate for loss of the neur gene. Here, we report the paralog of mouse Neur1, named
Neuralized-2 (Neur2), which is a ubiquitin-protein isopeptide ligase (E3) that interacts with …