Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development
C Leimeister, N Schumacher, M Gessler - Gene Expression Patterns, 2003 - Elsevier
The interaction of neighboring cells via Notch signalling leads to cell fate determination,
differentiation and patterning of highly organized tissues. Mice with targeted disruption of
genes from the Notch signal transduction pathway display defects in the developing somites,
neurogenic structures, blood vessels, heart and other organs. Recent studies have added
requirements for Notch signalling during kidney, pancreas and thymus morphogenesis.
Here, we describe the expression of all four receptors (Notch1–4), the five transmembrane …
differentiation and patterning of highly organized tissues. Mice with targeted disruption of
genes from the Notch signal transduction pathway display defects in the developing somites,
neurogenic structures, blood vessels, heart and other organs. Recent studies have added
requirements for Notch signalling during kidney, pancreas and thymus morphogenesis.
Here, we describe the expression of all four receptors (Notch1–4), the five transmembrane …