[HTML][HTML] Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway
L Elson-Schwab, OB Garner, M Schuksz… - Journal of biological …, 2007 - ASBMB
Facilitating the uptake of molecules into living cells is of substantial interest for basic
research and drug delivery applications. Arginine-rich peptides have been shown to
facilitate uptake of high molecular mass cargos into cells, but the mechanism of uptake is
complex and may involve multiple receptors. In this report, we show that a derivative of the
aminoglycoside antibiotic neomycin, in which all of the ammonium groups have been
converted into guanidinium groups, can carry large (> 300 kDa) bioactive molecules across …
research and drug delivery applications. Arginine-rich peptides have been shown to
facilitate uptake of high molecular mass cargos into cells, but the mechanism of uptake is
complex and may involve multiple receptors. In this report, we show that a derivative of the
aminoglycoside antibiotic neomycin, in which all of the ammonium groups have been
converted into guanidinium groups, can carry large (> 300 kDa) bioactive molecules across …