The plasma clearance of intestinally derived remnant lipoproteins by the liver is a process
that likely involves three steps. Our model suggests that the initial rapid clearance by the
liver begins with sequestration of the remnants within the space of Disse, where
apolipoprotein E secreted by hepatocytes enhances remnant binding and uptake. Heparan
sulfate proteoglycans (HSPG), which are also abundant in the space of Disse, mediate this
enhanced binding. Next, the remnants undergo further processing in the space of Disse by …