[HTML][HTML] Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase
Z Liu, HR Wang, CL Huang - Journal of biological chemistry, 2009 - ASBMB
WNK kinases are serine-threonine kinases with an atypical placement of the catalytic lysine.
WNK1, the first member discovered, has multiple alternatively spliced isoforms, including a
ubiquitously expressed full-length long form (L-WNK1) and a kidney-specific form (KS-
WNK1) predominantly expressed in the kidney. Intronic deletions of WNK1 that increase
WNK1 transcript cause pseudohypoaldosteronism type 2, an autosomal-dominant disease
characterized by hypertension and hyperkalemia. L-WNK1 inhibits renal K+ channel ROMK …
WNK1, the first member discovered, has multiple alternatively spliced isoforms, including a
ubiquitously expressed full-length long form (L-WNK1) and a kidney-specific form (KS-
WNK1) predominantly expressed in the kidney. Intronic deletions of WNK1 that increase
WNK1 transcript cause pseudohypoaldosteronism type 2, an autosomal-dominant disease
characterized by hypertension and hyperkalemia. L-WNK1 inhibits renal K+ channel ROMK …