Monocyte Chemotactic Protein–1 As A Chemoattractant for Human Hepatic Stellate Cells

F Marra, RG Romanelli, C Giannini, P Failli… - Hepatology, 1999 - journals.lww.com
Following liver injury, hepatic stellate cells (HSC) undergo proliferation and migrate into
damaged areas in response to chemotactic factors. HSC have been shown to regulate
leukocyte trafficking by secreting monocyte chemotactic protein–1 (MCP–1), a chemokine
that recruits monocytes and lymphocytes. In this study, we explored whether MCP–1 exerts
biological actions on HSC. HSC were isolated from normal human livers, cultured on plastic,
and studied in their myofibroblast–like phenotype, and three different cells lines were used …