Somatostatin inhibits adrenocorticotropin (ACTH) secretion from pituitary tumor cells. To
assess the contribution of somatostatin receptor subtype 5 (SST5) to somatostatin receptor
subtype 2 (SST2) action in these cells, we assessed multipathway responses to novel highly
monoreceptor-selective peptide agonists and multireceptor agonists, including octreotide
and somatostatin-28. Octreotide and somatostatin-28 cell membrane binding affinities
correlated with their respective SST2-selective peptide ligand. Although octreotide had …