Clinical manifestations of acromegaly

ME Molitch - Endocrinology and metabolism clinics of North America, 1992 - Elsevier
Pituitary tumors in patients with acromegaly are usually large and may cause problems
because of tumor mass and hormone over secretion. Mortality is increased two-to threefold
owing to cardiovascular, respiratory, and neoplastic causes. Early treatment may reverse the
diabetes, soft tissue changes, sleep apnea, and cardiovascular and neuromuscular disease.
The effect of treatment on neoplasia is unclear, and patients need screening, especially for
colon neoplasia.