Preoperative octreotide treatment in newly diagnosed acromegalic patients with macroadenomas increases cure short-term postoperative rates: a prospective …

SM Carlsen, M Lund-Johansen… - The Journal of …, 2008 - academic.oup.com
SM Carlsen, M Lund-Johansen, T Schreiner, S Aanderud, Ĝ Johannesen, J Svartberg…
The Journal of Clinical Endocrinology & Metabolism, 2008academic.oup.com
Context: Surgery is the primary treatment of acromegaly. However, it often fails to cure the
patient. New strategies that improve surgical outcome are needed. Objective: Our objective
was to investigate whether 6-month preoperative treatment with octreotide improves the
surgical outcome in newly diagnosed acromegalic patients. Patients: During a 5-yr period
(1999–2004), all newly diagnosed acromegalic patients between 18 and 80 yr of age in
Norway were screened and invited to participate in the study. A total of 62 patients was …
Abstract
Context: Surgery is the primary treatment of acromegaly. However, it often fails to cure the patient. New strategies that improve surgical outcome are needed.
Objective: Our objective was to investigate whether 6-month preoperative treatment with octreotide improves the surgical outcome in newly diagnosed acromegalic patients.
Patients: During a 5-yr period (1999–2004), all newly diagnosed acromegalic patients between 18 and 80 yr of age in Norway were screened and invited to participate in the study. A total of 62 patients was included in the Preoperative Octreotide Treatment of Acromegaly study.
Research Design and Methods: After a baseline evaluation, patients were randomized directly to transsphenoidal surgery (n = 30) or pretreatment with octreotide (n = 32) 20 mg im every 28th day for 6 months before transsphenoidal surgery. Cure was evaluated 3 months postoperatively primarily by IGF-I levels.
Results: According to the IGF-I criteria, 14 of 31 (45%) pretreated patients vs. seven of 30 (23%) patients with direct surgery were cured by surgery (P = 0.11). In patients with microadenomas (≤10 mm), one of five (20%) pretreated vs. three of five (60%) with direct surgery were cured (P = 0.52). In patients with macroadenomas, 13 of 26 (50%) pretreated vs. four of 25 (16%) with direct surgery were cured (P = 0.017).
Conclusions: Six-month preoperative octreotide treatment might improve surgical cure rate in newly diagnosed acromegalic patients with macroadenomas. These results have to be confirmed in future studies.
Oxford University Press