The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis
IJ Fidler - European Journal of Cancer (1965), 1973 - Elsevier
B 16 melanoma cells grown in vitro were used to study factors influencing experimental
metastasis. Groups of C57 BL/6, mice were given intravenous injections of varying numbers
of viable B 16 melanoma cells, with or without gamma-irradiated B 16 cells, viable B 16 cells
with or without C 57 embryo cells, and equal number of viable B 16 cells suspended singly
or in clumps. The data permitted the following conclusions: The number of lung metastases
was proportional to the number of viable tumor cells injected iv Mice injected with clumps of …
metastasis. Groups of C57 BL/6, mice were given intravenous injections of varying numbers
of viable B 16 melanoma cells, with or without gamma-irradiated B 16 cells, viable B 16 cells
with or without C 57 embryo cells, and equal number of viable B 16 cells suspended singly
or in clumps. The data permitted the following conclusions: The number of lung metastases
was proportional to the number of viable tumor cells injected iv Mice injected with clumps of …