Thymectomy in early childhood: Significant alterations of the CD4+ CD45RA+ CD62L+ T cell compartment in later life
M Prelog, M Keller, R Geiger, A Brandstätter… - Clinical …, 2009 - Elsevier
The study was aimed to assess indicators of immunosenescence, such as the total counts of
peripheral blood CD4+ CD45RA+ CD62L+ (naive) T cells, the numbers of T cell receptor
excision circles (TRECs), and Ki67-expression as marker of peripheral replication in
thymectomized patients (TP)(n= 101) compared to age-matched healthy donors (HD)(n=
81). In TP, there was an inverse correlation between naive T cells and chronological age (p<
0.001) or time post thymectomy (p< 0.001). TP demonstrated lower TREC numbers in naive …
peripheral blood CD4+ CD45RA+ CD62L+ (naive) T cells, the numbers of T cell receptor
excision circles (TRECs), and Ki67-expression as marker of peripheral replication in
thymectomized patients (TP)(n= 101) compared to age-matched healthy donors (HD)(n=
81). In TP, there was an inverse correlation between naive T cells and chronological age (p<
0.001) or time post thymectomy (p< 0.001). TP demonstrated lower TREC numbers in naive …