[HTML][HTML] RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate
E Moallem, R Kilav, J Silver, T Naveh-Many - Journal of Biological …, 1998 - ASBMB
Parathyroid hormone (PTH) regulates serum calcium and phosphate levels, which, in turn,
regulate PTH secretion and mRNA levels. PTH mRNA levels are markedly increased in rats
fed low calcium diets and decreased after low phosphate diets, and this effect is post-
transcriptional. Protein-PTH mRNA binding studies, with parathyroid cytosolic proteins,
showed three protein-RNA bands. This binding was to the 3′-untranslated region (UTR) of
the PTH mRNA and was dependent upon the terminal 60 nucleotides. Parathyroid proteins …
regulate PTH secretion and mRNA levels. PTH mRNA levels are markedly increased in rats
fed low calcium diets and decreased after low phosphate diets, and this effect is post-
transcriptional. Protein-PTH mRNA binding studies, with parathyroid cytosolic proteins,
showed three protein-RNA bands. This binding was to the 3′-untranslated region (UTR) of
the PTH mRNA and was dependent upon the terminal 60 nucleotides. Parathyroid proteins …