Identification of light chain type bands in CSF and serum oligoclonal IgG from patients with multiple sclerosis
PD Mehta, SP Mehta, BA Patrick - Journal of Neuroimmunology, 1982 - Elsevier
The light (L) chain types (kappa and lambda) of oligoclonal IgG bands of matching CSF and
serum from 10 MS patients were identified in immunofixation after isoelectric focusing in
polyacrylamide gel. Each specimen showed 10–15 oligoclonal bands in pH region of 7.5–
9.3. In 7 MS CSF and 5 sera a greater number of oligoclonal IgG bands were of kappa (κ)-
type whereas in 3 CSF and 2 sera the majority was of lambda (λ)-type. In 3 sera a clearcut
correlation of bands with either type of L chain was not observed due to diffuse staining …
serum from 10 MS patients were identified in immunofixation after isoelectric focusing in
polyacrylamide gel. Each specimen showed 10–15 oligoclonal bands in pH region of 7.5–
9.3. In 7 MS CSF and 5 sera a greater number of oligoclonal IgG bands were of kappa (κ)-
type whereas in 3 CSF and 2 sera the majority was of lambda (λ)-type. In 3 sera a clearcut
correlation of bands with either type of L chain was not observed due to diffuse staining …
