Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice
AS Verkman - Seminars in nephrology, 2008 - Elsevier
Transgenic mice lacking renal aquaporins (AQPs), or containing mutated AQPs, have been
useful in confirming anticipated AQP functions in renal physiology and in discovering new
functions. Mice lacking AQPs 1-4 manifest defects in urinary concentrating ability to different
extents. Mechanistic studies have confirmed the involvement of AQP1 in near-isosmolar fluid
absorption in the proximal tubule, and in countercurrent multiplication and exchange
mechanisms that produce medullary hypertonicity in the antidiuretic kidney. Deletion of …
useful in confirming anticipated AQP functions in renal physiology and in discovering new
functions. Mice lacking AQPs 1-4 manifest defects in urinary concentrating ability to different
extents. Mechanistic studies have confirmed the involvement of AQP1 in near-isosmolar fluid
absorption in the proximal tubule, and in countercurrent multiplication and exchange
mechanisms that produce medullary hypertonicity in the antidiuretic kidney. Deletion of …