[HTML][HTML] Phosphorylation of p40AUF1 regulates binding to A+ U-rich mRNA-destabilizing elements and protein-induced changes in ribonucleoprotein structure
GM Wilson, J Lu, K Sutphen, Y Suarez, S Sinha… - Journal of Biological …, 2003 - ASBMB
Messenger RNA turnover directed by A+ U-rich elements (AREs) involves selected ARE-
binding proteins. Whereas several signaling systems may modulate ARE-directed mRNA
decay and/or post-translationally modify specific trans-acting factors, it is unclear how these
mechanisms are linked. In THP-1 monocytic leukemia cells, phorbol ester-induced
stabilization of some mRNAs containing AREs was accompanied by dephosphorylation of
Ser 83 and Ser 87 of polysome-associated p40 AUF1. Here, we report that phosphorylation …
binding proteins. Whereas several signaling systems may modulate ARE-directed mRNA
decay and/or post-translationally modify specific trans-acting factors, it is unclear how these
mechanisms are linked. In THP-1 monocytic leukemia cells, phorbol ester-induced
stabilization of some mRNAs containing AREs was accompanied by dephosphorylation of
Ser 83 and Ser 87 of polysome-associated p40 AUF1. Here, we report that phosphorylation …