[HTML][HTML] Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage
DNA damage leads to stabilization and accumulation of p53, which plays a pivotal role in
transcriptional activation of p21 and cell cycle arrest. The increase in p53 stability depends
critically on its phosphorylation on serine/threonine residues, including those preceding a
proline (Ser (P)/Thr-Pro). The Ser (P)/Thr-Pro moiety exists in the two distinct cis and trans
conformations and their conversion is catalyzed specifically by the prolyl isomerase Pin1.
Pin1 regulates the conformation and function of certain phosphorylated proteins and plays …
transcriptional activation of p21 and cell cycle arrest. The increase in p53 stability depends
critically on its phosphorylation on serine/threonine residues, including those preceding a
proline (Ser (P)/Thr-Pro). The Ser (P)/Thr-Pro moiety exists in the two distinct cis and trans
conformations and their conversion is catalyzed specifically by the prolyl isomerase Pin1.
Pin1 regulates the conformation and function of certain phosphorylated proteins and plays …