Activated protein C in normal human pregnancy and pregnancies complicated by severe preeclampsia: a therapeutic opportunity?
P von Dadelszen, LA Magee, SK Lee… - Critical care …, 2002 - journals.lww.com
Objectives Given the efficacy and safety of recombinant human activated protein C (rhAPC)
in the systemic inflammatory response syndrome, this study was designed to review the
evidence for a role for APC in the pathogenesis of preeclampsia. Preeclampsia is a
proinflammatory and procoagulant state, and it is a pregnancy-specific condition that mimics
the systemic inflammatory response syndrome. rhAPC reduces mortality in patients with
systemic inflammatory response syndrome and could potentially have a role as disease …
in the systemic inflammatory response syndrome, this study was designed to review the
evidence for a role for APC in the pathogenesis of preeclampsia. Preeclampsia is a
proinflammatory and procoagulant state, and it is a pregnancy-specific condition that mimics
the systemic inflammatory response syndrome. rhAPC reduces mortality in patients with
systemic inflammatory response syndrome and could potentially have a role as disease …