Estrogen-induced cholestasis: clues to pathogenesis and treatment
AJ Schreiber, FR Simon - Hepatology, 1983 - journals.lww.com
Estrogen-related cholestasis has been of clinical interest for nearly three decades. The
clinical spectrum of intrahepatic cholestasis of pregnancy and pruritus gravidarum was first
characterized in 1955 (1-5). Although its pathogenesis remains unknown, epidemiologic
and experimental data suggest an inheritable abnormality in hepatic reactivity to circulating
estrogens. Oral contraceptives were introduced in 1960. It was soon observed that a small
percentage of women using these drugs develop intrahepatic cholestasis (6-10, Sotaniemi …
clinical spectrum of intrahepatic cholestasis of pregnancy and pruritus gravidarum was first
characterized in 1955 (1-5). Although its pathogenesis remains unknown, epidemiologic
and experimental data suggest an inheritable abnormality in hepatic reactivity to circulating
estrogens. Oral contraceptives were introduced in 1960. It was soon observed that a small
percentage of women using these drugs develop intrahepatic cholestasis (6-10, Sotaniemi …