Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice
N Ghebranious, S Sell - Hepatology, 1998 - journals.lww.com
The major risk factors for human liver cancer: hepatitis B virus (HBV) related liver injury,
male gender, aflatoxin exposure, and p53 expression, are evaluated and compared in
experimental transgenic mouse models. Transgenic mice that express hepatitis B surface
antigen (HBsAg) in their liver and develop liver tumors at 18 months of age (HBV+ mice)
were bred to p53 null mice (p53−/−) to produce mice p53+/−, HBV+ mice. These mice and
control litter-mates ([p53+/+, HBV+],[p53+/−, HBV−], and [p53+/+, HBV−]) were divided into …
male gender, aflatoxin exposure, and p53 expression, are evaluated and compared in
experimental transgenic mouse models. Transgenic mice that express hepatitis B surface
antigen (HBsAg) in their liver and develop liver tumors at 18 months of age (HBV+ mice)
were bred to p53 null mice (p53−/−) to produce mice p53+/−, HBV+ mice. These mice and
control litter-mates ([p53+/+, HBV+],[p53+/−, HBV−], and [p53+/+, HBV−]) were divided into …