GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein–protein interactions
AG Rosmarin, KK Resendes, Z Yang… - Blood Cells, Molecules …, 2004 - Elsevier
GA-binding protein (GABP) is an ets transcription factor that controls gene expression in
several important biological settings. It is unique among ets factors, since the
transcriptionally active complex is an obligate heterotetramer that is composed of two distinct
proteins. GABPα includes an ets DNA binding domain (DBD), while a distinct protein,
GABPβ, contains ankyrin repeats and the transcriptional activation domain (TAD). GABP
was first identified as a regulator of viral genes and nuclear respiratory factors. However …
several important biological settings. It is unique among ets factors, since the
transcriptionally active complex is an obligate heterotetramer that is composed of two distinct
proteins. GABPα includes an ets DNA binding domain (DBD), while a distinct protein,
GABPβ, contains ankyrin repeats and the transcriptional activation domain (TAD). GABP
was first identified as a regulator of viral genes and nuclear respiratory factors. However …