Transactivation by AP-1 is a molecular target of T cell clonal anergy
SM Kang, B Beverly, AC Tran, K Brorson, RH Schwartz… - Science, 1992 - science.org
SM Kang, B Beverly, AC Tran, K Brorson, RH Schwartz, MJ Lenardot
Science, 1992•science.orgAnergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in
the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-
induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the
transcription factor AP-1 and its corresponding cis element were specifically down-
regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness
and activity of the AP-1 element.
the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-
induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the
transcription factor AP-1 and its corresponding cis element were specifically down-
regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness
and activity of the AP-1 element.
Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.
AAAS