[HTML][HTML] Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway
PM Yao, I Tabas - Journal of Biological Chemistry, 2001 - ASBMB
Macrophage death in advanced atherosclerotic lesions leads to lesional necrosis and
possibly plaque rupture and acute vascular occlusion. Among the likely causes of lesional
macrophage death is intracellular accumulation of excess free cholesterol (FC), which is
known to occur in vivo. We recently showed that FC loading of macrophages causes
apoptosis,∼ 50% of which is mediated by activation of cell-surface FasL and triggering of
the Fas pathway (Yao, PM, and Tabas, I.(2000) J. Biol. Chem. 275, 23807–23813). To …
possibly plaque rupture and acute vascular occlusion. Among the likely causes of lesional
macrophage death is intracellular accumulation of excess free cholesterol (FC), which is
known to occur in vivo. We recently showed that FC loading of macrophages causes
apoptosis,∼ 50% of which is mediated by activation of cell-surface FasL and triggering of
the Fas pathway (Yao, PM, and Tabas, I.(2000) J. Biol. Chem. 275, 23807–23813). To …