Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase
Muscle proteolysis from catabolic conditions, including chronic kidney disease, requires
coordinated activation of both the apoptotic and ATP-ubiquitin-proteasome systems (Ub-
P'some), including upregulation of components of the Ub-P'some system. Activation of the
apoptotic system is required because caspase-3 initially cleaves myofibrils, yielding
substrates for the Ub-P'some system plus a characteristic 14-kD actin fragment. The authors
studied insulin deficiency, a model of accelerated muscle atrophy, to understand how …
coordinated activation of both the apoptotic and ATP-ubiquitin-proteasome systems (Ub-
P'some), including upregulation of components of the Ub-P'some system. Activation of the
apoptotic system is required because caspase-3 initially cleaves myofibrils, yielding
substrates for the Ub-P'some system plus a characteristic 14-kD actin fragment. The authors
studied insulin deficiency, a model of accelerated muscle atrophy, to understand how …