Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy

JL Bailey, B Zheng, Z Hu, SR Price… - Journal of the American …, 2006 - journals.lww.com
Complications of chronic kidney disease (CKD) include depressed responses to insulin/IGF-
1 and accelerated muscle proteolysis as a result of activation of caspase-3 and the ubiquitin-
proteasome system. Experimentally, proteolysis in muscle cells occurs when there is
suppression of phosphatidylinositol 3-kinase (PI3-K) activity. Postreceptor signaling through
the insulin receptor substrate (IRS)/PI3-K/Akt pathway was evaluated in muscles of acidotic,
CKD and pair-fed control rats under physiologic conditions and in response to a dose of …