The signaling adaptors and pathways activated by TNF superfamily
PW Dempsey, SE Doyle, JQ He, G Cheng - Cytokine & growth factor …, 2003 - Elsevier
Members of the TNF receptor superfamily play pivotal roles in numerous biological events in
metazoan organisms. Ligand-mediated trimerization by corresponding homo-or
heterotrimeric ligands, the TNF family ligands, causes recruitment of several intracellular
adaptors, which activate multiple signal transduction pathways. While recruitment of death
domain (DD) containing adaptors such as Fas associated death domain (FADD) and TNFR
associated DD (TRADD) can lead to the activation of a signal transduction pathway that …
metazoan organisms. Ligand-mediated trimerization by corresponding homo-or
heterotrimeric ligands, the TNF family ligands, causes recruitment of several intracellular
adaptors, which activate multiple signal transduction pathways. While recruitment of death
domain (DD) containing adaptors such as Fas associated death domain (FADD) and TNFR
associated DD (TRADD) can lead to the activation of a signal transduction pathway that …