[HTML][HTML] Tumor necrosis factor-α increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up …

Z Yao, P Li, Q Zhang, EM Schwarz, P Keng… - Journal of Biological …, 2006 - ASBMB
Osteoclasts are essential cells for bone erosion in inflammatory arthritis and are derived
from cells in the myeloid lineage. Recently, we reported that tumor necrosis factor-α (TNFα)
increases the blood osteoclast precursor (OCP) numbers in arthritic patients and animals,
which are reduced by anti-TNF therapy, implying that circulating OCPs may have an
important role in the pathogenesis of erosive arthritis. The aim of this study is to investigate
the mechanism by which TNFα induces this increase in OCP frequency. We found that TNFα …