Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.
WS May, PG Tyler, T Ito, DK Armstrong… - Journal of Biological …, 1994 - ASBMB
Using murine myeloid factor-dependent FDC-P1/ER cells, we demonstrate that the
hematopoietic growth factors interleukin-3 and erythropoietin and bryostatin-1, a macrocyclic
lactone natural product and potent activator of protein kinase C (PKC), suppress apoptosis
and induce the rapid serine phosphorylation of Bc12 alpha. Expression of recombinant wild
type Bc12 alpha in NFS/N1. H-7 cells confirms that murine Bc12 alpha is phosphorylated
following PKC activation. The PKC inhibitors H-7 and staurosporine, but not the protein …
hematopoietic growth factors interleukin-3 and erythropoietin and bryostatin-1, a macrocyclic
lactone natural product and potent activator of protein kinase C (PKC), suppress apoptosis
and induce the rapid serine phosphorylation of Bc12 alpha. Expression of recombinant wild
type Bc12 alpha in NFS/N1. H-7 cells confirms that murine Bc12 alpha is phosphorylated
following PKC activation. The PKC inhibitors H-7 and staurosporine, but not the protein …