Characterisation of human cyclin G1 and G2: DNA damage inducible genes.

S Bates, S Rowan, KH Vousden - Oncogene, 1996 - europepmc.org
S Bates, S Rowan, KH Vousden
Oncogene, 1996europepmc.org
Several genes have been identified as targets for transcriptional activation by the p53
tumour suppressor protein. Rodent cyclin G was previously identified as a p53 responsive
gene and in order to assess the role played by cyclin G as a mediator of p53 function in
humans cells we have isolated full length human cyclin G1 and identified a related gene
designated cyclin G2. Both human G-cyclins are induced by the DNA damaging agent
actinomycin-D and although the induction of cyclin G1 is clearly p53 dependent, activation of …
Several genes have been identified as targets for transcriptional activation by the p53 tumour suppressor protein. Rodent cyclin G was previously identified as a p53 responsive gene and in order to assess the role played by cyclin G as a mediator of p53 function in humans cells we have isolated full length human cyclin G1 and identified a related gene designated cyclin G2. Both human G-cyclins are induced by the DNA damaging agent actinomycin-D and although the induction of cyclin G1 is clearly p53 dependent, activation of cyclin G2 expression was observed in the absence of p53. Based on sequence similarity, the G-cyclins and the recently identified cyclin I form a distinct sub-group within the larger cyclin family, possibly reflecting some degree of functional similarity.
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