[HTML][HTML] Endothelial activation: intracellular signaling pathways
JS Pober - Arthritis Research & Therapy, 2002 - Springer
Arthritis Research & Therapy, 2002•Springer
Chapter summary Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine
and endothelial cells are the principal cellular targets of its actions. Here I review the
responses of endothelial cells to TNF, with emphasis on the induction of endothelial
leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal
transduction in TNF-treated endothelial cells that lead to the expression of adhesion
molecules.
and endothelial cells are the principal cellular targets of its actions. Here I review the
responses of endothelial cells to TNF, with emphasis on the induction of endothelial
leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal
transduction in TNF-treated endothelial cells that lead to the expression of adhesion
molecules.
Chapter summary
Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.
Springer