T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
B Olsson, PO Andersson, M Jernås, S Jacobsson… - Nature medicine, 2003 - nature.com
B Olsson, PO Andersson, M Jernås, S Jacobsson, B Carlsson, LMS Carlsson, H Wadenvik
Nature medicine, 2003•nature.comChronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is
characterized by increased platelet destruction and is believed to be autoantibody mediated.
In this study, CD3+ T cells from ITP patients had increased expression of genes involved in
cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets
was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative
mechanism for platelet destruction in ITP.
characterized by increased platelet destruction and is believed to be autoantibody mediated.
In this study, CD3+ T cells from ITP patients had increased expression of genes involved in
cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets
was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative
mechanism for platelet destruction in ITP.
Abstract
Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
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