CD24 (heat stable antigen, nectadrin), a novel keratinocyte differentiation marker, is preferentially expressed in areas of the hair follicle containing the colony-forming …

T Magnaldo, Y Barrandon - Journal of cell science, 1996 - journals.biologists.com
Journal of cell science, 1996journals.biologists.com
We have isolated, by subtractive and differential hybridization from a library constructed from
keratinocyte colonyforming cells (K-CFCs), a cDNA coding for the rat CD24 (nectadrin, heat
stable antigen). CD24, a glycoprotein thought to be involved in cell-cell adhesion and
signalling, is highly expressed in keratinocytes located in the bulge area of the rat vibrissa
which contains the most K-CFCs. CD24 is also expressed in the outer epithelial sheath of
human hair follicles and in glabrous epidermis. However, its expression is not restricted to K …
Abstract
We have isolated, by subtractive and differential hybridization from a library constructed from keratinocyte colonyforming cells (K-CFCs), a cDNA coding for the rat CD24 (nectadrin, heat stable antigen). CD24, a glycoprotein thought to be involved in cell-cell adhesion and signalling, is highly expressed in keratinocytes located in the bulge area of the rat vibrissa which contains the most K-CFCs. CD24 is also expressed in the outer epithelial sheath of human hair follicles and in glabrous epidermis. However, its expression is not restricted to K-CFCs as demonstrated by cell sorting experiments, and it is thus not a specific marker of clonogenic keratinocytes. Rather, its preferential distribution in keratinocytes located in the most innervated area of the rat vibrissal follicle, i.e. the bulge, suggests that its function could be related to the tactile role of the hair follicle.
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