[HTML][HTML] Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin
M Dickens, CA Svitek, AA Culbert, RM O'Brien… - Journal of Biological …, 1998 - ASBMB
Transcription of the gene encoding the catalytic subunit of glucose-6-phosphatase (G6Pase)
is stimulated by glucocorticoids and strongly repressed by insulin. We have explored the
signaling pathways by which insulin mediates the repression of G6Pase transcription in
H4IIE cells. Wortmannin, a phosphatidylinositide 3-kinase (PtdIns 3-kinase) inhibitor blocked
the repression of G6Pase mRNA expression by insulin. However, both rapamycin, which
inhibits p70S6 kinase activation, and PD98059, an inhibitor of mitogen-activated protein …
is stimulated by glucocorticoids and strongly repressed by insulin. We have explored the
signaling pathways by which insulin mediates the repression of G6Pase transcription in
H4IIE cells. Wortmannin, a phosphatidylinositide 3-kinase (PtdIns 3-kinase) inhibitor blocked
the repression of G6Pase mRNA expression by insulin. However, both rapamycin, which
inhibits p70S6 kinase activation, and PD98059, an inhibitor of mitogen-activated protein …