Plasma concentrations of the hormone gastrin are elevated by Helicobacter pylori infection
and by gastric atrophy. It has previously been proposed that gastrin acts as a cofactor during
gastric carcinogenesis and hypergastrinemic transgenic INS-GAS mice are prone to
developing gastric adenocarcinoma, particularly following H. pylori infection. We
hypothesised that the increased risk of carcinogenesis in these animals may partly result
from altered susceptibility of gastric epithelial cells to undergo apoptosis. Gastric corpus …